Elucidating the spectrum of alpha thalassemia mutations in iran

Thus, low the mean corpuscular volume (MCV) and the mean corpuscular hemoglobin (MCH) may consider as α-thalassemia key detection points.

The present study aimed to determine the prevalence of microcytosis among neonates who born in Tehran, Iran.

The alpha (HBA1, 141800; HBA2, 141850) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A.

Mutant beta globin that sickles causes sickle cell anemia (603903).

The clue for a thalassemia comes with a low mean corpuscular volume (MCV) or mean corpuscular hemoglobin (MCH).

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Background: Identification of α thalassemia (α thal) a common cause of microcytosis during neonatal periods is an important step prevent unnecessary interventions.

The entire gene, including the coding, intervening and untranslated regions, is transcribed into a colinear 15S m RNA precursor.

Because mature globin m RNA is smaller (10S) and does not contain the intervening sequences, the 15S precursor must be processed. (1978) prepared a map of the human beta- and delta- (142000) globin genes.

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